• Dr. David B. Mancuso

CV

Dr. David B. Mancuso serves as Executive Director of Pharmacy and Laboratory Services at Nicklaus Children’s Hospital, where he leads the integration of precision medicine into pediatric clinical practice.

With extensive experience in pharmacogenomics, gene and enzyme replacement therapies, and advanced molecular diagnostics, Dr. Mancuso has developed and implemented clinical pathways for complex and genetic diseases.

His work focuses on translating genomic insights into actionable treatment strategies, optimizing therapeutic outcomes, and enhancing safety in pediatric populations.

ABSTRACT

One Test, a Lifetime of Impact: Pre-emptive PGx Testing in Pediatric Care

Pharmacogenomics (PGx) is revolutionizing the way we approach medication management, especially in pediatrics, where early intervention can shape a lifetime of health outcomes. This presentation explores the transformative potential of pre-emptive PGx testing in pediatric care, highlighting how a single genetic test panel can inform safer, more effective prescribing from childhood through adulthood.

We will examine the clinical and operational benefits of integrating PGx into pediatric workflows, including reduced adverse drug reactions, improved therapeutic efficacy, and long-term cost savings. Real-world case studies will illustrate how early genetic insights can guide treatment decisions across medical specialties.

Attendees will gain a clear understanding of implementation strategies, ethical considerations, and the evolving evidence base supporting PGx in children. By investing in one test early in life, healthcare systems can deliver personalized medicine that grows with the patient—empowering clinicians, reassuring families, and ultimately improving outcomes.