{"id":4049,"date":"2025-09-22T17:14:23","date_gmt":"2025-09-22T15:14:23","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=4049"},"modified":"2025-09-22T17:14:23","modified_gmt":"2025-09-22T15:14:23","slug":"schwab-matthias","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/schwab-matthias\/","title":{"rendered":"Schwab Matthias"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-4f913bbd7e39b280b2db5ca8e8e2db78.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-4f913bbd7e39b280b2db5ca8e8e2db78.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-4f913bbd7e39b280b2db5ca8e8e2db78 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-4f913bbd7e39b280b2db5ca8e8e2db78 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-4f913bbd7e39b280b2db5ca8e8e2db78 alignnone  vc_custom_1758554000095 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20500&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Schwab_foto-500x500.jpg\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Schwab_foto-500x500.jpg 500w, https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Schwab_foto.jpg 622w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/schwab_foto\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Dr.\u00a0Schwab Matthias<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-536869f32fa1e4ca8\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-536869f32fa1e4ca8 uvc-4917 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-536869f32fa1e4ca8 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-536869f32fa1e4ca8 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Professor at the University of Tuebingen, head of the Department of Clinical Pharmacology, University Hospital Tuebingen and the Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany. Schwab holds board certifications in Pediatrics and in Clinical Pharmacology, and was visiting professor at St Jude Children\u2019s Research Hospital Memphis, USA. Schwab\u2019s focus lies on personalized medicine and the elucidation of underlying mechanisms for drug failure and side effects, and on cancer pharmacogenomics (PGx), the application of omics-technologies and ex-vivo models. He is PI of academically initiated drug trials, received funding on European\/national level, and is engaged in the implementation of PGx into clinics. He is member of the German National Academia of Sciences Leopoldina, Academia of Sciences&amp;Literature Mainz, Academia Europea, and Fellow of the British Pharmacology Society. He is adjunct professor at the Yerevan State University Armenia, Clarivate Highly Cited Researcher and serves as (Section-)Editor-in-Chief of Pharmacogenetics&amp;Genomics and Drug Research.<\/div><\/div><div id=\"ultimate-heading-854969f32fa1e4d0a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-854969f32fa1e4d0a uvc-6745 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-854969f32fa1e4d0a h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-854969f32fa1e4d0a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>CYP2D6 and tamoxifen: current status<\/strong><\/p>\n<p><u>Schwab<\/u> (1), (2)<\/p>\n<p>(1) Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstr. 112, 70376 Stuttgart, Germany<\/p>\n<p>(2) Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany<\/p>\n<p>&nbsp;<\/p>\n<p>Variation in drug disposition and response among breast cancer patients is a major concern. Estrogen receptor (ER)-positive breast cancer accounts for 75% of cases diagnosed worldwide. The two main options for adjuvant treatment are tamoxifen and aromatase inhibitors. Research into PGx has led to fundamental discoveries regarding whether genetic polymorphisms of <em>CYP2D6 <\/em>may influence the outcome of tamoxifen treatment. Based on the fact that the pharmacokinetics of tamoxifen and the formation of the active metabolite endoxifen are altered by <em>CYP2D6<\/em> variation, a higher risk of recurrence in postmenopausal breast cancer women is associated with the <em>CYP2D6<\/em> genotype when strict clinical and genotype eligibility requirements are used. Therefore, testing for the <em>CYP2D6<\/em> genotype is recommended prior to tamoxifen therapy. However, several pitfalls in tamoxifen PGx research contribute to conflicting results, including a lack of consideration of the germline and tumour genome and insufficient coverage of <em>CYP2D6<\/em> alleles for genetic diagnostics, as well as challenges in translating PGx recommendations into clinical practice. Various therapeutic strategies to overcome impaired CYP2D6-mediated tamoxifen metabolism are discussed. The addition of a low dose of (Z)-endoxifen to standard tamoxifen therapy is a feasible and safe novel strategy for personalised antiestrogen treatment, as has recently been demonstrated.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4049","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/4049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=4049"}],"version-history":[{"count":1,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/4049\/revisions"}],"predecessor-version":[{"id":4052,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/4049\/revisions\/4052"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=4049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}