{"id":3986,"date":"2025-09-22T16:16:25","date_gmt":"2025-09-22T14:16:25","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=3986"},"modified":"2025-09-22T16:47:09","modified_gmt":"2025-09-22T14:47:09","slug":"van-gelder-teun","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/van-gelder-teun\/","title":{"rendered":"Van Gelder Teun"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-7a74806a479240a3041b1134ca5f5fc8.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-7a74806a479240a3041b1134ca5f5fc8.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-7a74806a479240a3041b1134ca5f5fc8 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-7a74806a479240a3041b1134ca5f5fc8 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-7a74806a479240a3041b1134ca5f5fc8 alignnone  vc_custom_1758550534863 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20500&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/van-Gelder_foto-500x500.jpg\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/van-Gelder_foto-500x500.jpg 500w, https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/van-Gelder_foto-1000x1000.jpg 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/lumc-portretten\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Prof. Van Gelder Teun<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-870769f2fb0f12c20\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-870769f2fb0f12c20 uvc-8566 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-870769f2fb0f12c20 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-870769f2fb0f12c20 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Prof. Teun van Gelder is an internist trained in nephrology and clinical pharmacology.\u00a0 From 1988 -2019 he worked at the Erasmus Medical Center in Rotterdam. In December 2019 Teun accepted a new position in Leiden University Medical Center as Professor in Drug Discovery &amp; Development. In this role he is responsible for the research theme Academic Pharma. He combines clinical work (kidney transplantation and clinical pharmacology) with teaching and research (10 PhD students). He was the chair of the Dutch Society for Clinical Pharmacology &amp; Biopharmacy and the president of the International Association for Therapeutic Drug Monitoring and Clinical Toxicology.<\/div><\/div><div id=\"ultimate-heading-889069f2fb0f12c61\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-889069f2fb0f12c61 uvc-5060 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-889069f2fb0f12c61 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;margin-top:50px;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-889069f2fb0f12c61 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Pharmacogenetics in solid organ transplantation: ready for implementation?<\/strong><\/p>\n<p>The immunosuppressive drugs used in solid organ transplantation have narrow therapeutic ranges and highly variable pharmacokinetics between individuals. The most frequently prescribed drug is tacrolimus, of which the exposure strongly correlates with the expression and activity of the metabolizing enzymes cytochrome P450 (CYP) 3A4 and CYP3A5. These enzymes are polymorphically expressed, which is in part explained by the presence of single-nucleotide polymorphisms in the CYP3A4 and CYP3A5 genes.\u00a0 There are striking differences in the prevalence of the different genotypes among patients with varying ethnicity. The higher dose requirement of patients expressing CYP3A5 may cause a delay in reaching the desired tacrolimus target concentrations, potentially with reduced efficacy as a result. The question is whether the implementation of pre-transplantation genotyping will benefit patient management.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3986","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3986","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=3986"}],"version-history":[{"count":3,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3986\/revisions"}],"predecessor-version":[{"id":4013,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3986\/revisions\/4013"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=3986"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}