{"id":3941,"date":"2025-09-22T15:18:08","date_gmt":"2025-09-22T13:18:08","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=3941"},"modified":"2025-09-22T15:18:08","modified_gmt":"2025-09-22T13:18:08","slug":"ingelman-sundberg-magnus","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/ingelman-sundberg-magnus\/","title":{"rendered":"Ingelman-Sundberg Magnus"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-bd111353005c8b7af3a664edb95a3ed9.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-bd111353005c8b7af3a664edb95a3ed9.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-bd111353005c8b7af3a664edb95a3ed9 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-bd111353005c8b7af3a664edb95a3ed9 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-bd111353005c8b7af3a664edb95a3ed9 alignnone  vc_custom_1758547036394 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20500&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Ingelman-Sundberg_foto-scaled-500x500.jpg\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Ingelman-Sundberg_foto-scaled-500x500.jpg 500w, https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Ingelman-Sundberg_foto-scaled-1000x1000.jpg 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/fyfa-magnus-ingelman-sundberg\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Magnus Ingelman-Sundberg, PhD; BSc.Med<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-21769f2fb0f8d438\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-21769f2fb0f8d438 uvc-5043 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-21769f2fb0f8d438 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-21769f2fb0f8d438 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Magnus Ingelman-Sundberg, PhD; BSc.Med is Senior Professor of Molecular Toxicology and research group leader in Pharmacogenetics at the Department of Physiology and Pharmacology, Karolinska Institutet. He has more than 520 original papers and a h-factor of 101 (ISI\/Clarivate) or 132 (Google Scholar). Assigned \u201cHighly Cited Researcher\u201d for 2014-2017 and 2021-2024 &nbsp;by Thomson &amp; Reuters\/Clarivate. He is ranked #18 most cited scientists of 21,811 in pharmaceutical science according to AD Scientific Index 2025. He was a member of <em>The Nobel Assembly <\/em>at Karolinska Institutet 2008-2018 and a member of Several Editorial Advisory Boards. He has received numerous Awards, most recently The RT Williams ISSX award, an honorary doctorship at SydDansk University and the Big silver Medal at Karolinska Institute<em>. <\/em>His research focuses on genetics, polymorphism, regulation, function and toxicology of the hepatic ADME system with aims at understanding interindividual differences in drug response. Furthermore he develops novel hepatic <em>in vitro <\/em>systems for studying liver function, liver diseases, siRNA action and metabolism and validation of hepatic drug targets.<\/div><\/div><div id=\"ultimate-heading-750969f2fb0f8d478\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-750969f2fb0f8d478 uvc-8913 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-750969f2fb0f8d478 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;margin-top:50px;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-750969f2fb0f8d478 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Bridging the Gap: understanding missing heritability in pharmacogenomics<\/strong><\/p>\n<p>Missing heritability\u2014where identified genetic variants explain only a fraction of observed heritability\u2014poses a significant challenge. This gap limits the ability to fully account for inter-individual variability in drug response, hindering the development of precise therapeutic strategies. Missing heritability in pharmacogenomics stems from rare variants, structural variations, epigenetic modifications, and complex gene-environment interactions that are often overlooked in traditional genome-wide association studies (GWAS). These studies primarily focus on common single nucleotide polymorphisms (SNPs), which may not capture the full genetic architecture influencing drug metabolism and response. Addressing this issue requires advanced methodologies, such as whole-genome sequencing, multi-omics integration, and machine learning, to uncover rare variants, haplotype influence and non-genetic factors. Additionally, diverse population studies are essential to reduce bias and enhance generalizability. By tackling missing heritability, pharmacogenomics can improve predictive models, optimize drug dosing, minimize adverse reactions, and advance equitable precision medicine. Prioritizing this challenge will bridge the gap between genetic potential and clinical application, ensuring more effective and personalized therapeutic outcomes.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3941","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=3941"}],"version-history":[{"count":2,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3941\/revisions"}],"predecessor-version":[{"id":3943,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3941\/revisions\/3943"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=3941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}