{"id":3915,"date":"2025-09-22T12:52:47","date_gmt":"2025-09-22T10:52:47","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=3915"},"modified":"2025-09-22T12:53:01","modified_gmt":"2025-09-22T10:53:01","slug":"elens-laure","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/elens-laure\/","title":{"rendered":"Elens Laure"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-6558304b51e9be5b2e1ac082224dafd8.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-6558304b51e9be5b2e1ac082224dafd8.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-6558304b51e9be5b2e1ac082224dafd8 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-6558304b51e9be5b2e1ac082224dafd8 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-6558304b51e9be5b2e1ac082224dafd8 alignnone  vc_custom_1758538374399 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20217%20217&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Elens_foto-217x217.png\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Elens_foto-217x217.png 217w\" loading=\"eager\" sizes=\"(max-width: 217px) 100vw, 217px\" width=\"217\" height=\"217\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/elens_foto\/\" style=\"--ratio: 217 \/ 217;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Prof. Laure Elens<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-406669ef850d63c41\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-406669ef850d63c41 uvc-3532 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-406669ef850d63c41 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-406669ef850d63c41 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Prof. Laure Elens is a Professor of Pharmacokinetics at the Faculty of Pharmacy and Biomedical Sciences of UCLouvain in Brussels, where she conducts research at the Louvain Drug Research Institute (LDRI). Her research focuses on understanding interindividual variability in drug response, with a particular emphasis on host-related factors. She investigates how gut microbiota, pharmacogenetic variations (such as polymorphisms in drug-metabolizing enzymes, transporters, and targets), comedications (acting as enzyme or transporter modulators), and other host-related determinants influence pharmacokinetic and pharmacodynamic profiles. While her work is particularly centered on immunosuppressive therapies, it also extends to antiretroviral, anticancer, antibiotic, and statin treatments. By integrating clinical pharmacology, pharmacogenetics, and systems pharmacokinetics, Prof. Elens aims to advance personalized medicine in transplantation and beyond.<\/div><\/div><div id=\"ultimate-heading-625269ef850d63c82\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-625269ef850d63c82 uvc-5393 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-625269ef850d63c82 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;margin-top:50px;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-625269ef850d63c82 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Crosstalk Between Gut Microbiome and Immunosuppressive Drugs in Kidney Transplantation<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>In kidney transplantation, achieving optimal immunosuppression while minimizing toxicity and rejection remains a major challenge. Emerging evidence highlights the gut microbiome as a key host factor influencing drug disposition and therapeutic outcomes. This talk will explore the dynamic interplay between gut microbial communities and immunosuppressive drugs, focusing on agents such as tacrolimus and mycophenolate mofetil. Prof. Laure Elens will present data illustrating how microbial composition and activity can modulate drug metabolism, absorption, and enterohepatic recycling, thereby contributing to interindividual variability in pharmacokinetics and pharmacodynamics. The role of microbial enzymes, such as \u03b2-glucuronidases, and microbial-derived metabolites will be discussed and the complexity of host-drug-microbiome interactions will be highlighted. By integrating clinical pharmacology, pharmacogenetics, and microbiome science, this presentation aims to shed light on novel strategies for personalizing immunosuppressive therapy in transplant recipients. Ultimately, understanding these interactions may pave the way for microbiome-informed therapeutic monitoring approaches, enabling better control of immunosuppression and potentially improving long-term transplant outcomes.<\/p>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3915","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=3915"}],"version-history":[{"count":3,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3915\/revisions"}],"predecessor-version":[{"id":3918,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3915\/revisions\/3918"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=3915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}