{"id":3880,"date":"2025-09-22T12:17:15","date_gmt":"2025-09-22T10:17:15","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=3880"},"modified":"2025-09-22T15:19:01","modified_gmt":"2025-09-22T13:19:01","slug":"alix-panabieres-catherine","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/alix-panabieres-catherine\/","title":{"rendered":"Alix-Panabieres Catherine"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-663fe3301562b811af1be8334cda0032.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-663fe3301562b811af1be8334cda0032.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-663fe3301562b811af1be8334cda0032 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-663fe3301562b811af1be8334cda0032 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-663fe3301562b811af1be8334cda0032 alignnone  vc_custom_1758536128592 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20500&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Alix-Panabieres_foto-2-500x500.png\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Alix-Panabieres_foto-2-500x500.png 500w, https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Alix-Panabieres_foto-2-1000x1000.png 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/alix-panabieres_foto-2\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Prof. Alix-Panabieres Catherine<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-108369f30c9aebd7b\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-108369f30c9aebd7b uvc-5107 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-108369f30c9aebd7b h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-108369f30c9aebd7b .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Catherine Alix-Panabi\u00e8res is Professor of Oncology and Director of the Laboratory of Rare Human Circulating Cells and Liquid Biopsy (LCCRH) at Montpellier University Hospital and the Faculty of Medicine. Since 2022, she has also been Professor at the University of Hamburg, Germany. A pioneer in circulating tumor cell (CTC) research for over 25 years, she introduced the term liquid biopsy in 2010 together with Prof. Pantel. She teaches internationally, has organized numerous conferences, and has contributed over 170 publications, book chapters, and patents. Her landmark work demonstrated the clinical utility of CTCs in breast cancer. Prof. Alix-Panabi\u00e8res has received multiple national and international awards, including the \u201cGallet et Breton\u201d Prize (2012) and the \u201cBerthe P\u00e9an, Antoine et Claude B\u00e9cl\u00e8re\u201d Prize (2023) from the French Academy of Medicine. In 2020, Nature highlighted her contributions to liquid biopsy as a major cancer research breakthrough of the past two decades.<\/div><\/div><div id=\"ultimate-heading-73069f30c9aebdd3\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-73069f30c9aebdd3 uvc-5947 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-73069f30c9aebdd3 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;margin-top:50px;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-73069f30c9aebdd3 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Unravelling the biology of metastasis-competent circulating tumor cells: insights into the metastatic cascade<\/strong><\/p>\n<p>The characterization of circulating tumor cells (CTCs) offers valuable opportunities for precision medicine, as these cells serve as important clinical indicators of treatment efficacy and disease progression. We established the first\u2014and still only\u2014nine permanent colon CTC lines from peripheral blood samples of a patient with metastatic colon cancer, collected at different time points during therapy and progression. The study aimed (i) to compare gene expression profiles across these CTC lines and (ii) to identify features acquired under treatment pressure. A higher number of genes were upregulated in post-treatment CTC lines, reflecting adaptive mechanisms for survival. Among them, genes involved in the mTOR and PI3K\/AKT signaling pathways were significantly enriched. Notably, cytidine deaminase expression was increased after failure of 5-fluorouracil-based regimens, suggesting enzymatic drug inactivation. Enzymes implicated in xenobiotic metabolism were also upregulated, indicating the activation of detoxification mechanisms in response to chemotherapy. Furthermore, aldolase B was markedly overexpressed in CTC lines obtained after treatment withdrawal, consistent with a liver metastasis origin. Beyond transcriptional changes, I will present complementary data on epigenomic reprogramming, describe the major hallmarks of CTCs, and highlight the mechanobiological properties that underlie their capacity to seed metastases. Collectively, these unique CTC lines provide critical insights into tumor evolution, drug resistance, and metastatic potential.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3880","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3880","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=3880"}],"version-history":[{"count":5,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3880\/revisions"}],"predecessor-version":[{"id":3946,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3880\/revisions\/3946"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=3880"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}