{"id":3870,"date":"2025-09-22T12:14:13","date_gmt":"2025-09-22T10:14:13","guid":{"rendered":"https:\/\/www.esptcongress.org\/?page_id=3870"},"modified":"2025-09-22T12:37:48","modified_gmt":"2025-09-22T10:37:48","slug":"akkers-robert","status":"publish","type":"page","link":"https:\/\/www.esptcongress.org\/index.php\/akkers-robert\/","title":{"rendered":"Akkers Robert"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;1\/4&#8243;]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-da4432a91fce3570b6b0a1a6a516c6b6.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-da4432a91fce3570b6b0a1a6a516c6b6.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-da4432a91fce3570b6b0a1a6a516c6b6 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-da4432a91fce3570b6b0a1a6a516c6b6 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-da4432a91fce3570b6b0a1a6a516c6b6 alignnone  vc_custom_1758535976764 enable-bg-rollover dt-icon-bg-off\" ><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20500%20500&#39;%2F%3E\" data-src=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Akkers_foto-500x500.jpg\" data-srcset=\"https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Akkers_foto-500x500.jpg 500w, https:\/\/www.esptcongress.org\/wp-content\/uploads\/2025\/09\/Akkers_foto-1000x1000.jpg 1000w\" loading=\"eager\" sizes=\"(max-width: 500px) 100vw, 500px\" width=\"500\" height=\"500\"  data-dt-location=\"https:\/\/www.esptcongress.org\/index.php\/speakers\/robert-akkers-portret-result-lab-moleculair-bioloog\/\" style=\"--ratio: 500 \/ 500;\" alt=\"\" \/><\/div><\/div><\/div><div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li>Dr. Robert Akkers<\/li>\n<\/ul>\n<\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-582569f2778b56953\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-582569f2778b56953 uvc-8927 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-582569f2778b56953 h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">CV<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-582569f2778b56953 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Dr. Robert Akkers is a molecular biologist at Result Laboratorium and a trainee Clinical Molecular Biologist in Pathology at the University Medical Center Utrecht (UMC Utrecht).<\/p>\n<p>Within this combined role, his work focuses on the clinical implementation of pharmacogenetics and targeted therapies, aiming to improve treatment outcomes through personalized medicine. He is particularly interested in how genetic variation influences drug response and therapy selection. By integrating molecular insights into routine diagnostic workflows, he contributes to the advancement of precision medicine and the development of more effective, personalized treatment strategies.<\/p>\n<p>&nbsp;<\/p>\n<p><\/div><\/div><div id=\"ultimate-heading-999069f2778b5699b\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-999069f2778b5699b uvc-5443 color-title accent-title-color uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-999069f2778b5699b h2'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h2 style=\"--font-weight:theme;\">ABSTRACT<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-999069f2778b5699b .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Unlocking Clinical Value in Pharmacogenetic Testing: Real-life Insights from the Lab<\/strong><\/p>\n<p><em>\u00a0<\/em><\/p>\n<p>Pharmacogenetic testing is transforming drug therapy by enabling personalized treatment strategies, minimizing adverse reactions, and enhancing clinical outcomes. Over the past three years, we have routinely applied a comprehensive pharmacogenomics application powered by Next-Generation Sequencing (NGS) in clinical diagnostics. This high-resolution approach accurately detects clinically relevant variants in key pharmacogenes such as CYP2D6, CYP2C19, DPYD, and others.<\/p>\n<p>Our NGS-based approach goes beyond conventional genotyping by capturing both rare variants and copy number variations (CNVs), thereby offering a more complete genetic profile. In our diagnostic population, we identified rare but clinically actionable variants in approximately 1\u20132% of patients per pharmacogene, underscoring the added value of NGS in precision medicine.<\/p>\n<p>We also present the first results from the updated pharmacogenomics application (SOPHiA DDM\u2122 Community Extended Pharmacogenomics Solution), now including relevant HLA genes. Additionally, we report on the new generation of SOPHiA DDM\u2122 Platform, an upgrade that improves both technical performance and ease of use.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3870","page","type-page","status-publish","hentry","description-off"],"_links":{"self":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3870","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/comments?post=3870"}],"version-history":[{"count":9,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3870\/revisions"}],"predecessor-version":[{"id":3912,"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/pages\/3870\/revisions\/3912"}],"wp:attachment":[{"href":"https:\/\/www.esptcongress.org\/index.php\/wp-json\/wp\/v2\/media?parent=3870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}